The Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) started a process to develop a new strategy for 2017-2021 early this year. The strategy will be the roadmap used to guide the Global Fund during a critical period during which high impact interventions must be scaled up in order to achieve an end to HIV, tuberculosis (TB) and malaria. The purpose of this Advocacy Alert is to share information with civil society about opportunities to shape the content of the 2017-2021 Strategy. This Advocacy Alert summarizes the process and priorities under consideration and provides a timeline of key milestones. Civil society advocates working to accelerate an end to the epidemics have a key role to play in shaping the Global Fund’s next strategy to ensure a bold, ambitious strategy based on community priorities.